Latuda dose escalation was safe and effective among adults with acute schizophrenia and inadequate initial response to standard doses, with a modest increase in certain adverse events (including akathisia, anxiety and. Results demonstrate a benefit to increasing LATUDA dose in patients who inadequate initial response to standard dose Latuda® (lurasidone HCI). akathisia, insomnia, and somnolence compared with patients who. not possible to observe a consistent dose-response relationship. common side effects with Latuda (which may affect more than 1 in 10 people) are akathisia.
Although he did not complain he told his peers that he felt he was jumping out of his skin. In view of these side-effects his medications were switched to olanzapine, titrated to 10 mg at bedtime, which controlled his symptoms. Subsequently, the patient gained more than 23 kg over one year and continued exhibiting negative symptoms, some depression and some obsessive-compulsive symptoms. Aripiprazole was continued with follow-up one week later.
The patient returned, denying anxiety but complaining of his inability to sit or stand still. It was noted that he was constantly fidgeting a lot, which had never been noted earlier. The patient also stated that he could not tolerate this symptom, he refused to continue with this medication, and stated that he wanted to return to olanzapine. Aripiprazole was therefore discontinued. Olanzapine was restarted at 7. Discussion The following factors may be related to the development of akathisia in the cases described in this report.
Akathisia secondary to conventional antipsychotic agents is frequently attributed to D2 receptor blockade in the mesocortical areas Marsden and Jenner It is likely that this mechanism may also cause akathisia secondary to treatment with aripiprazole.
CYP2D6 is inhibited by fluoxetine and paroxetine, which may in turn inhibit aripiprazole breakdown and thus increase its blood levels. SSRIs may also cause akathisia, perhaps a consequence of sero-tonergically mediated inhibition of the dopaminergic system Lane All of the patients reported in this case series were on a SSRI.
Furthermore, the risk of akathisia secondary to SSRI treatment may be heightened by the concomitant use of an antipsychotic medication Gerber and Lynd Lastly, patients with affective symptoms have an increased risk of developing EPS and akathisia. All patients included in this report were diagnosed with schizoaffective disorder.
Lurasidone for the treatment of bipolar depression: an evidence-based review
In summary it is noted that aripiprazole did cause symptoms of akathisia in patients who had not experienced their symptoms on their previous antipsychotic agents.
These symptoms appeared to be dose-related. It appears that decreasing the dose in at least two cases caused a resolution of their symptoms.Latuda 2 Month Review + Update
There was no correlation between the onset, severity, or resolution of akathisia with clinical symptoms for the patients described in this report. We feel that akathisia may be dose-related, particularly in cases in which there is an additional SSRI.
Dose-dependent rapid-onset akathisia with aripiprazole in patients with schizoaffective disorder
Further investigation into the risk of akathisia secondary to aripiprazole treatment may be beneficial. Aripiprazole, a novel antipsychotic is a high affinity partial agonist at human D2 dopamine receptors.
J Pharmacol Exp Ther. Extrapyramidal side effects associated with aripiprazole coprescription in two patients. The Cochrane Database of Systematic Reviews. Selective serotonin reuptake inhibitor induced movement disorders.
What You Need to Know About Latuda (lurasidone).
Aripiprazole; A review of its use in schizophrenia and schizoaffective disorder. The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor.
SSRI induced extra pyramidal side effects and akathisia: Aripiprazole in the treatment of schizophrenia: The pathophysiology of extrapyramidal side-effects of neuroleptic drugs.
Late or missed menstrual period Breast enlargement Doctors recommend that you not drink alcohol while on the medication. It also is recommended that you wait to drive or operate machinery until you know how the medication affects you. Report major side effects to your doctor immediately, which can include difficulty swallowing or breathing, sore throat, swelling, shortness of breath, abnormal heartbeat, fever, cough, chills, sweating, confusion, muscle stiffness, and unusual facial or body movements.
What are the potential long-term effects of taking Latuda? Your doctor should monitor for progression of potential long-term side effect of atypical antipsychotics, which can include tardive dyskinesia TD.
Atypical antipsychotics may also increase the risk of cardiovascular side effects, diabetes, weight gain, and high cholesterol. Is it safe for a woman who is pregnant, about to become pregnant, or nursing to take Latuda? There have been no controlled human pregnancy studies on the effects of Latuda, but exposure to antipsychotic medication during the third trimester of pregnancy can lead to withdrawal symptoms in infants after delivery.
It is not known whether the drug can be transferred via human breast milk and harm a baby, but animal studies indicate the drug may be present in breast milk and potentially harm a nursing infant.
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Therefore, talk to your doctor if you are pregnant, planning to become pregnant, or are nursing before you take Latuda.